Calpain May Contribute to Hereditary Cataract Formation in Sheep
Investigative Ophthalmology & Visual Science2005Vol. 46(12), pp. 4634–4634
Citations Over TimeTop 18% of 2005 papers
Lucinda J. G. Robertson, James D. Morton, Masazumi Yamaguchi, R. Bickerstaffe, Thomas R. Shearer, Mitsuyoshi Azuma
Abstract
The presence of calpains and calcium elevation during cataract formation suggests that proteolysis may play a role in opacification in ovine lens. This hypothesis is supported by the delay in opacification with SJA6017 treatment. The results also suggested that the ovine hereditary cataract is a useful nonrodent model to test the role of calpains in cataractogenesis.
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