Monosomy of Chromosome 3 and an Inflammatory Phenotype Occur Together in Uveal Melanoma
Investigative Ophthalmology & Visual Science2008Vol. 49(2), pp. 505–505
Citations Over TimeTop 10% of 2008 papers
Willem Maat, Long V. Ly, Ekaterina S. Jordanova, D. de Wolff–Rouendaal, Nicoline E. Schalij‐Delfos, Martine J. Jager
Abstract
Monosomy 3 in uveal melanoma is associated with the presence of an inflammatory phenotype, consisting of a high HLA class I and II expression as well as an increased number of tumor-infiltrating macrophages. In a multivariate Cox regression analysis, the presence of monosomy 3 was one of the best prognostic markers of metastatic disease and survival, although the follow-up time was short.
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