Susceptibility of Ovine Lens Crystallins to Proteolytic Cleavage during Formation of Hereditary Cataract
Investigative Ophthalmology & Visual Science2008Vol. 49(3), pp. 1016–1016
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Lucinda J. G. Robertson, Larry L. David, Michael A. Riviere, Phillip A. Wilmarth, Matthew S. Muir, James D. Morton
Abstract
These data provide the first 2-DE gel maps for ovine lens crystallins and indicated that ovine lens crystallins are truncated during lens maturation. The differences in proteolysis appearing in normal and cataractous lenses suggested that calpain isoforms may be differentially activated during lens maturation and cataract. The ovine hereditary cataract is a useful nonrodent model to study the role of calpain proteolysis in cataract formation.
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