Gelatinase Expression in Retinoblastoma: Modulation of LHBETATAGRetinal Tumor Development by Anecortave Acetate
Investigative Ophthalmology & Visual Science2010Vol. 51(6), pp. 2860–2860
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M. L. Bajenaru, Yolanda Piña, Timothy G. Murray, Colleen M. Cebulla, William J. Feuer, Maria-Elena Jockovich, Maria-Encarna Marin Castaño
Abstract
As suggested by our data, inhibition of gelatinase activity appears to be a mechanism of action of AA. AA treatment results in a decrease in gelatinase activity that correlates with the significant decrease in tumor burden shown by the authors' previous studies. However, the significance of the initial, transient upregulation of gelatinase by AA injection is unknown, and further studies are warranted. Combining antiangiogenic agents with multiple mechanisms of action has the potential to enhance RB tumor control.
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