Retinal Vascular Rescue of Oxygen-Induced Retinopathy in Mice by Norrin
Investigative Ophthalmology & Visual Science2012Vol. 54(1), pp. 222–222
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Abstract
Modulation of Wnt-signaling improves retinal vascularization and accelerates vascular recovery after induction of retinopathy in the OIR mouse. Activation of Wnt-signaling (norrin) and inhibition of Wnt-canonical signaling (DKK1) result in similar improvement, indicating that norrin promotes improved vascularization, at least in part, by way of noncanonical Wnt-signaling.
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