A Prospective Longitudinal Study of Retinal Structure and Function in Achromatopsia
Investigative Ophthalmology & Visual Science2014Vol. 55(9), pp. 5733–5733
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Jonathan Aboshiha, Adam M. Dubis, Jill A. Cowing, Rachel T. A. Fahy, Venki Sundaram, James Bainbridge, Robin R. Ali, Alfredo Dubra, Marko Nardini, Andrew R. Webster, Anthony T. Moore, Gary S. Rubin, Joseph Carroll, Michel Michaelides
Abstract
Previously published cross-sectional studies have described conflicting findings with respect to the age-dependency of progression. This study, which constitutes the largest and longest prospective longitudinal study of ACHM to date, suggests that although ACHM may be progressive, any such progression is slow and subtle in most patients, and does not correlate with age or genotype. We also describe the first serial assessment of FAF, which is highly variable between individuals, even of similar age and genotype.
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