Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration
Investigative Ophthalmology & Visual Science2017Vol. 58(7), pp. 2977–2977
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Riccardo Natoli, Nilisha Fernando, Haihan Jiao, Tanja Racic, Michele C. Madigan, Nigel L. Barnett, Joshua A. Chu‐Tan, Krisztina Valter, Jan Provis, Matt Rutar
Abstract
These findings implicate C3, produced locally by retinal microglia/macrophages, as contributing causally to retinal degeneration. Consequently, this suggests that C3-targeted gene therapy may prove valuable in slowing the progression of AMD.
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