Two contrasting roles for Notch activity in chick inner ear development:specification of prosensory patches and lateral inhibition of hair-cell differentiation
Citations Over TimeTop 10% of 2005 papers
Abstract
Lateral inhibition mediated by Notch is thought to generate the mosaic of hair cells and supporting cells in the inner ear, but the effects of the activated Notch protein itself have never been directly tested. We have explored the role of Notch signalling by transiently overexpressing activated Notch (NICD) in the chick otocyst. We saw two contrasting consequences, depending on the time and site of gene misexpression: (1) inhibition of hair-cell differentiation within a sensory patch; and (2) induction of ectopic sensory patches. We infer that Notch signalling has at least two functions during inner ear development. Initially, Notch activity can drive cells to adopt a prosensory character, defining future sensory patches. Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells.
Related Papers
- → Two contrasting roles for Notch activity in chick inner ear development:specification of prosensory patches and lateral inhibition of hair-cell differentiation(2005)233 cited
- → Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates(2016)94 cited
- → Rbpj regulates development of prosensory cells in the mammalian inner ear(2011)77 cited
- → Patterning and cell fate in the inner ear: a case for Notch in the chicken embryo(2012)55 cited
- → Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear(2015)4 cited