Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis
Citations Over TimeTop 10% of 1995 papers
Abstract
Anterior/posterior compartment borders bisect every Drosophila imaginal disc, and the engrailed gene is essential for their function. We analyzed the role of the engrailed and invected genes in wing discs by eliminating or increasing their activity. Removing engrailed/invected from posterior wing cells created two new compartments: an anterior compartment consisting of mutant cells and a posterior compartment that grew from neighboring cells. In some cases, these compartments formed a complete new wing. Increasing engrailed activity also affected patterning. These findings demonstrate that engrailed both directs the posterior compartment pathway and creates the compartment border. These findings also establish the compartment border as the pre-eminent organizational feature of disc growth and patterning.
Related Papers
- → Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis(1995)252 cited
- → Compartments in the wing of Drosophila: A study of the engrailed gene(1976)296 cited
- → polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs(2000)38 cited
- → Transdetermination in imaginal wing disc fragments of Drosophila melanogaster(1983)4 cited
- → 03-P058 Wingless signaling and the control of cell shape in Drosophila wing imaginal discs(2009)