Improved Skin Delivery of Voriconazole with a Nanostructured Lipid Carrier-Based Hydrogel Formulation
Citations Over TimeTop 14% of 2014 papers
Abstract
In order to develop topical preparations of voriconazole (VRC) for the treatment of mycotic infections of the skin, a nanostructured lipid carrier-based hydrogel (NLC-gel) formulation was developed and its physical characteristics, in vitro skin permeation, and retention profiles were examined. A VRC-loaded NLC dispersion, consisting of Precirol ATO 5, Labrafil 1944 CS, and Tween 80, was prepared by high-pressure homogenization and embedded into Carbopol 940 hydrogel. The lipid nanoparticles in the hydrogel were approximately 210 nm in size, with a spherical shape and zeta potential of -30 mV. In a skin permeation study using a Franz diffusion cell mounted with depilated mouse skin, the NLC-gel was superior to conventional cream and microemulsion-based gel formulations, showing 2.8- and 1.7-fold greater flux values, respectively. In addition, the NLC-gel led to markedly greater accumulation of VRC in deeper skin layers as compared with the reference formulations. In conclusion, the novel topical formulation reported here represents an alternative treatment for skin infections such as candidiasis, with less potential for systemic adverse effects than oral therapy.
Related Papers
- → Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications(2018)289 cited
- → Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs(2015)204 cited
- → Injectable microgel–hydrogel composites “plum pudding gels”: new system for prolonged drug delivery(2019)17 cited
- → Crosslinked natural hydrogels for drug delivery systems(2022)6 cited
- → An Overview of the Recent Developments in Hydrogels(2021)3 cited