Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo
Diabetes2009Vol. 58(12), pp. 2766–2775
Citations Over TimeTop 10% of 2009 papers
Dale S. Edgerton, Christopher J. Ramnanan, Carrie A. Grueter, Kathryn Johnson, Margaret Lautz, Doss W. Neal, Phillip E. Williams, Alan D. Cherrington
Abstract
Gluconeogenic flux can be rapidly inhibited by high insulin levels in canines. Initially decreased hepatic lactate extraction is important, and later reduced gluconeogenic precursor availability plays a role. Changes in PEPCK appear to have little or no acute effect on gluconeogenic flux.
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