<i>Clostridium difficile</i> Toxin B: Insights into Its Target Genes

Abstract

Clostridium difficile is a grossly Gram-positive anaerobic bacterium that has been a key factor in inducing imbalances in the gut microbiota in recent years, leading to intestinal-associated inflammation. The main pathogenic toxins of Clostridium difficile are toxin A (TcdA) and toxin B (TcdB). TcdB is the main pathogenic factor of Clostridium difficile infection. This review revealed the pathogenic mechanism of Clostridium difficile toxin B, expounded the impact of Clostridium difficile on the intestinal system, and predicted the genes on which TcdB may act, thereby providing a new therapeutic target for Clostridium difficile infection, offering theoretical basis and new strategies for clinical prevention and control.

Related Papers

• → Binary Toxin–Producing, Large Clostridial Toxin–NegativeClostridium difficileStrains Are Enterotoxic but Do Not Cause Disease in Hamsters(2006)199 cited
• → Virulence of new variant strains of Clostridium difficile producing only toxin A or binary toxin in the hamster model(2019)19 cited
• → <i>Clostridium difficile</i> Toxin B: Insights into Its Target Genes(2022)1 cited
• → Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile -Associated Diarrhea(2005)22 cited
• → Novel One-Step Method for Detection and Isolation of Active-Toxin-Producing Clostridium difficile Strains Directly from Stool Samples(2011)21 cited