Assessment of the General Oxidant Status of Individuals in Non-Invasive Samples | doi.page

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Assessment of the General Oxidant Status of Individuals in Non-Invasive Samples

InTech eBooks2012

Sandro Argelles, Mercedes Cano, F. Mario, Rafael Ayala, Afrah Ismaiel, A. Rosenberg Ayal

Abstract

Determination of the oxidative stress state of a person indicates the risk of suffering many disorders and diseases in humans that are a product of oxidative stress. The oxidant status of an individual is assessed by determining a group of markers in non-invasive samples. Although these biomarkers are formed by oxidation of biomolecules and are supposed to reflect changes in tissues that have been exposed to oxidants, one limitation when measuring these biomarkers in non-invasive samples is that they do not give information about the tissue localization of the oxidative stress, at the least the marker is exported into serum from the tissue. In previous work from our laboratory, we have determined that only a few generic markers of oxidation can be useful to predict the oxidant status of an individual when the markers are measured in non invasive samples. An additional aspect to consider before validating the markers is to determine how stable their levels are for the same individual throughout time. Theoretically, if these markers present a high variability, their utility to study the effects of an eventual intervention would be limited since the effects of the intervention should be clear to be observed over the basal oscillation of the marker. Results from our group show a significant intra day variation of serum biomarkers in many cases. Therefore, it is clear that more than a single measurement will be required to establish the basal status of oxidative stress of individuals and several measurements will be required for a long period of time.

Abstract

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