Jack A. Kauffman
Nationwide Children's Hospital(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Blood Coagulation and Thrombosis Mechanisms, Biochemical and Structural Characterization, Platelet Disorders and Treatments, Heparin-Induced Thrombocytopenia and Thrombosis
Most-Cited Works
- → Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.(1993)109 cited
- → A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase(2005)92 cited
- → Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions(1995)87 cited
- → Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone(2003)82 cited
- → Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308(1999)71 cited
- → Comparison of the action of types A and F botulinum toxin at the rat neuromuscular junction(1985)68 cited
- → In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design(2004)67 cited
- → Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group(1996)65 cited
- → 1,2,4-Triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists(2001)54 cited
- → Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design(2002)50 cited