Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group
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Abstract
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTPotent Thrombin Inhibitors That Probe the S1' Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group 1Michael J. Costanzo, Bruce E. Maryanoff, Leonard R. Hecker, Mary R. Schott, Stephen C. Yabut, Han-Cheng Zhang, Patricia Andrade-Gordon, Jack A. Kauffman, Joan M. Lewis, Raman Krishnan, and Alexander TulinskyView Author Information Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, and Department of Chemistry, Michigan State University, East Lansing, Michigan 48824Cite this: J. Med. Chem. 1996, 39, 16, 3039–3043Publication Date (Web):August 2, 1996Publication History Received2 May 1996Published online2 August 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm9603274https://doi.org/10.1021/jm9603274rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views646Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Heterocyclic compounds,Inhibition,Inhibitors,Noncovalent interactions,Peptides and proteins Get e-Alerts
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