Adrian J. Highton
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Asymmetric Synthesis and Catalysis, Bone Metabolism and Diseases, Cyclopropane Reaction Mechanisms, Microbial Natural Products and Biosynthesis
Most-Cited Works
- → Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle(2018)76 cited
- → Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice(2021)42 cited
- → (1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis(2012)39 cited
- → Synthesis of the Asperparaline Core by a Radical Cascade(2011)37 cited
- → A Very Rapid Stereocontrolled Entry to Highly Functionalized [5-8-5] Ring Systems Using the Saegusa Reaction(1999)37 cited
- → Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis(2012)29 cited
- → Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors(2012)22 cited
- → Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides(2022)14 cited
- → Double Ring-Opening Reactions of Bis-Cyclopropanes Promoted by Iron Salts(1999)8 cited
- → Novel features of iron-mediated radical reactions: an unusual mode of silyloxycyclopropane fission, and a new method for radical chain termination using CH2I2(2004)7 cited