Keith R. Hornberger
Arvinas (United States)(US)
Publications by Year
Research Areas
Melanoma and MAPK Pathways, Protein Degradation and Inhibitors, Microtubule and mitosis dynamics, Catalytic C–H Functionalization Methods, Catalytic Cross-Coupling Reactions
Most-Cited Works
- → Protein degraders enter the clinic — a new approach to cancer therapy(2023)558 cited
- → Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors(2013)254 cited
- → Total Synthesis of Leucascandrolide A(2000)185 cited
- → Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders(2023)128 cited
- → Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor(2009)63 cited
- → Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding(2009)61 cited
- → Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B-RafV600E mutation(2009)54 cited
- → Room-Temperature Pd-Catalyzed Amidation of Aryl Bromides Using tert-Butyl Carbamate(2009)46 cited
- → Synthetic Utility of Yeast Hexokinase. Substrate Specificity, Cofactor Regeneration, and Product Isolation(1997)42 cited
- → A mild, one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines(2006)40 cited