Room-Temperature Pd-Catalyzed Amidation of Aryl Bromides Using tert-Butyl Carbamate
The Journal of Organic Chemistry2009Vol. 74(12), pp. 4634–4637
Citations Over TimeTop 11% of 2009 papers
Abstract
The scope of Pd-catalyzed synthesis of N-Boc-protected anilines from aryl bromides and commercially available tert-butyl carbamate is described. For the first time, this process can be conducted at room temperature (17-22 degrees C) using a combination of Pd(2)dba(3).CHCl(3) and a monodentate ligand, tert-butyl X-Phos. Use of sodium tert-butoxide is crucial to the success of the reaction, which proceeds in 43-83% yield.
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