Brian Aquila
AstraZeneca (United States)(US)
Publications by Year
Research Areas
Radical Photochemical Reactions, Melanoma and MAPK Pathways, Cell death mechanisms and regulation, Catalytic C–H Functionalization Methods, Click Chemistry and Applications
Most-Cited Works
- → Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia(2018)480 cited
- → Photoredox Mediated Nickel Catalyzed Cross-Coupling of Thiols With Aryl and Heteroaryl Iodides via Thiyl Radicals(2016)442 cited
- → Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross‐Coupling of Primary Aryl Amines with Aryl Halides(2016)209 cited
- → Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain(2016)192 cited
- → A study of the reactivity of S(VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions(2017)157 cited
- → Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)(2013)113 cited
- → Effects of Molecular Oxygen, Solvent, and Light on Iridium-Photoredox/Nickel Dual-Catalyzed Cross-Coupling Reactions(2015)89 cited
- → β-Functionalization of Saturated Aza-Heterocycles Enabled by Organic Photoredox Catalysis(2021)53 cited
- → Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design(2020)48 cited