Michael DeGraffenreid
Publications by Year
Research Areas
Hormonal Regulation and Hypertension, Adrenal and Paraganglionic Tumors, Adrenal Hormones and Disorders, Cancer-related Molecular Pathways, Click Chemistry and Applications
Most-Cited Works
- → Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3(2014)70 cited
- → Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model▽(2008)42 cited
- → Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors(2010)42 cited
- → Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1(2008)38 cited
- → An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters(2007)27 cited
- → Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)(2009)25 cited
- → Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors(2009)22 cited
- → Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit(2011)21 cited
- → Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors(2010)18 cited
- → The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors(2010)18 cited