Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
Bioorganic & Medicinal Chemistry Letters2011Vol. 21(18), pp. 5206–5209
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Matthew L. Brown, Wade H. Aaron, Richard J. Austin, Angela Chong, Tom Huang, Ben Jiang, Jacob A. Kaizerman, Gary Lee, Brian S. Lucas, Dustin L. McMinn, Jessica Orf, Minqing Rong, Maria M. Toteva, Guifen Xu, Qiuping Ye, Wendy Zhong, Michael DeGraffenreid, Dineli Wickramasinghe, Jay P. Powers, Randall W. Hungate, Michael G. Johnson
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