John W. Butcher
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Hepatitis C virus research, Neuroscience and Neuropharmacology Research, Ion channel regulation and function, HIV/AIDS drug development and treatment, Chemical Synthesis and Analysis
Most-Cited Works
- → Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor(2012)201 cited
- → Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase(1999)196 cited
- → Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor(2010)176 cited
- → Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease(2008)134 cited
- → Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide(1997)94 cited
- → An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride(1993)79 cited
- → Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters(1990)73 cited
- → A new series of potent benzodiazepine γ-secretase inhibitors(2003)58 cited
- → Synthesis of semisynthetic dipeptides using N-carboxyanhydrides and chiral induction on Raney nickel. A method practical for large scale(1988)53 cited
- → Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B SelectiveN-Methyl-d-Aspartate Receptor Antagonist(2007)45 cited