Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
Citations Over TimeTop 23% of 1997 papers
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTClass III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamideHarold G. Selnick, Nigel J. Liverton, John J. Baldwin, John W. Butcher, David A. Claremon, Jason M. Elliott, Roger M. Freidinger, Stella A. King, Brian E. Libby, Charles J. McIntyre, David A. Pribush, David C. Remy, Garry R. Smith, Andrew J. Tebben, Nancy K. Jurkiewicz, Joseph J. Lynch, Joseph J. Salata, Michael C. Sanguinetti, Peter K. S. Siegl, Donald E. Slaughter, and Kamlesh VyasView Author Information Departments of Medicinal Chemistry, Pharmacology, and Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486 Cite this: J. Med. Chem. 1997, 40, 24, 3865–3868Publication Date (Web):November 21, 1997Publication History Received4 August 1997Published online21 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/jm970517uhttps://doi.org/10.1021/jm970517urapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views644Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Azides,Molecular structure,Potassium,Receptors Get e-Alerts
Related Papers
- → Synthesis of trifluoromethyl or trifluoroacetyl substituted heterocyclic compounds from trifluoromethyl‐α,β‐ynones(2022)14 cited
- → Reactions of trifluoromethyl ketones. IX. Investigation of the steric effect of a trifluoromethyl group based on the stereochemistry on the dehydration of trifluoromethyl homoallyl alcohols(1992)41 cited
- → A new synthesis for methyl/trifluoromethyl organometallic compounds by low temperature cocondensation of trifluoromethyl radicals and main group methyl alkyls(1983)11 cited
- → 1,1,2‐Triphenylethylenes with trifluoromethyl substituents(1966)4 cited
- Susquehanna Chorale Spring Concert "Roots and Wings"(2017)