Constantin G. Yannopoulos
Vertex Pharmaceuticals (Canada)(CA)
Publications by Year
Research Areas
Hepatitis C virus research, HIV/AIDS drug development and treatment, Hepatitis B Virus Studies, Biochemical and Molecular Research, DNA and Nucleic Acid Chemistry
Most-Cited Works
- → Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors(2005)194 cited
- → Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase(2003)192 cited
- → Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides(2004)101 cited
- → Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides(2004)76 cited
- → Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition(2006)74 cited
- → Synthesis of Antisense Oligonucleotides Conjugated to a Multivalent Carbohydrate Cluster for Cellular Targeting(2002)71 cited
- → Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase(2003)68 cited
- → The Differential Regulation by Glucagon and Growth Hormone of Insulin-Like Growth Factor (IGF)-I and IGF Binding Proteins in Cultured Rat Hepatocytes*(1991)65 cited
- → Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors(2008)58 cited
- → Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors(2005)28 cited