Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase
Journal of Medicinal Chemistry2003Vol. 46(8), pp. 1283–1285
Citations Over TimeTop 10% of 2003 papers
Laval Chan, T. Jagadeeswar Reddy, Mélanie Proulx, Sanjoy Das, Oswy Z. Pereira, Wuyi Wang, Arshad Siddiqui, Constantin G. Yannopoulos, Carl Poisson, Nathalie Turcotte, Alexandre Drouin, Moulay Hicham Alaoui-Ismaili, Richard C. Bethell, Martine Hamel, Lucille L’Heureux, Darius Bilimoria, Nghe Nguyen‐Ba
Abstract
The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.
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