Nicholas Smithers
Publications by Year
Research Areas
Protein Degradation and Inhibitors, Histone Deacetylase Inhibitors Research, Ubiquitin and proteasome pathways, Multiple Myeloma Research and Treatments, Cancer-related gene regulation
Most-Cited Works
- → Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains(2013)302 cited
- → The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway(2013)208 cited
- → Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762(2013)202 cited
- → Selective inhibition of CD4 + T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors(2012)184 cited
- → CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development(2011)154 cited
- → Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation(2014)140 cited
- → TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK(2017)98 cited
- → Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling(2015)86 cited
- → The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes(2014)73 cited
- → Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival(2015)69 cited