Seb Caille
Amgen (United States)(US)Université Bourgogne Franche-Comté(FR)
Publications by Year
Research Areas
Asymmetric Hydrogenation and Catalysis, Asymmetric Synthesis and Catalysis, Chemical Synthesis and Reactions, Crystallization and Solubility Studies, Hormonal Regulation and Hypertension
Most-Cited Works
- → Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry(2019)99 cited
- → Highly Enantioselective Hydrogenation of Styrenes Directed by 2′-Hydroxyl Groups(2011)88 cited
- → Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase(2016)64 cited
- → Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model▽(2008)43 cited
- → Multi-Kilo Delivery of AMG 925 Featuring a Buchwald–Hartwig Amination and Processing with Insoluble Synthetic Intermediates(2015)41 cited
- → Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters(2008)36 cited
- → Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor(2022)30 cited
- → Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid(2021)27 cited
- → Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes(2022)27 cited
- → Kinetic Investigations To Enable Development of a Robust Radical Benzylic Bromination for Commercial Manufacturing of AMG 423 Dihydrochloride Hydrate(2020)24 cited