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Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)
ChemMedChem2022Vol. 17(19)
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Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaâ Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie A. Chapeau, Markus Wartmann, Clemens Scheufler, César Fernández Fernández, Joerg Kallen, Vito Guagnano, Patrick Chêne, Tobias Schmelzle
Abstract
The Front Cover shows a representative of the first class of potent disrupters of the YAP-TEAD interaction in complex with TEAD. This molecule inhibits the transcriptional activity of TEAD, leading to a robust cellular antiproliferative effect. More information can be found in the Research Article by Pascal Furet, Vito Guagnano, Patrick Chène, Tobias Schmelzle, et al.
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