Highly Modular Synthesis of 1,2-Diketones via Multicomponent Coupling Reactions of Isocyanides as CO Equivalents
ACS Catalysis2019Vol. 9(5), pp. 4508–4515
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Anne‐Marie Dechert‐Schmitt, Michelle R. Garnsey, Hanna M. Wisniewska, James I. Murray, Taegyo Lee, Daniel W. Kung, Neal W. Sach, Donna G. Blackmond
Abstract
A one-pot, four-component Pd-catalyzed coupling has been developed for the synthesis of unsymmetrical 1,2-diketones from aryl halides and alkyl zincs employing tert-butyl isocyanide as a CO source. The intermediate 1,2-diketones have been elaborated to quinoxalines. Mechanistic studies help to rationalize the high selectivity for the bis- vs monoinsertion product.
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