Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors
Journal of Medicinal Chemistry2004Vol. 47(26), pp. 6603–6608
Citations Over TimeTop 12% of 2004 papers
Ariamala Gopalsamy, Kitae Lim, Gregory Ciszewski, Kaapjoo Park, John W. Ellingboe, Jonathan D. Bloom, Shabana Insaf, Janis Upeslacis, Tarek S. Mansour, Girija Krishnamurthy, Murthy Damarla, Yelena Pyatski, Douglas M. Ho, Anita Y. M. Howe, Mark Orlowski, Boris Feld, Juliette O’Connell
Abstract
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
Related Papers
- → Effect of Interaction between Hepatitis C Virus NS5A and NS5B on Hepatitis C Virus RNA Replication with the Hepatitis C Virus Replicon(2004)99 cited
- → Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors(2004)60 cited
- → Identification of a novel replication-competent hepatitis C virus variant that confers the sofosbuvir resistance(2021)6 cited
- → HCV Replicon Inhibitors: Mode of Action and Resistance Mapping(2004)
- The Advance on Research of RNA-dependent RNA Polymerase(RdRp) of Hepatitis C Virus.(2000)