Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Journal of Medicinal Chemistry2011Vol. 55(2), pp. 914–923
Citations Over TimeTop 12% of 2011 papers
Matthew F. Brown, Usa Reilly, J. A. Abramite, Joel T. Arcari, Robert M. Oliver, Rose A. Barham, Ye Che, Jinshan Michael Chen, Elizabeth M. Collantes, Seung Won Chung, Charlene Desbonnet, Jonathan L. Doty, Matthew Doroski, Juntyma J. Engtrakul, Thomas M. Harris, Michael D. Huband, John D. Knafels, Karen L. Leach, Shenping Liu, Anthony Marfat, Andrea Marra, Eric B. McElroy, Michael Melnick, Carol A. Menard, Justin I. Montgomery, Lisa Mullins, Mark C. Noe, John P. O’Donnell, Joseph Penzien, Mark S. Plummer, Loren Price, Veerabahu Shanmugasundaram, Christy L. Thoma, Daniel P. Uccello, Joseph S. Warmus, Donn G. Wishka
Abstract
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid.
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