3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors
ACS Medicinal Chemistry Letters2014Vol. 5(4), pp. 428–433
Citations Over Time
Emmanuel Pinard, Daniela Alberati, Rubén Alvarez‐Sánchez, Virginie Brom, Serge Burner, Holger Fischer, Nicole Hauser, Sabine Kolczewski, Judith A. Lengyel, Roland Mory, Christian Saladin, Tanja Schulz‐Gasch, Henri Stalder
Abstract
3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.
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