Formal Palladium-Catalyzed Asymmetric Hydrogenolysis of Racemic N-Sulfonyloxaziridines
Organic Letters2015Vol. 17(2), pp. 190–193
Citations Over TimeTop 14% of 2015 papers
Abstract
Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.
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