Multifaceted folding in a foldamer featuring highly cooperative folds
Chemical Communications2012Vol. 48(91), pp. 11205–11205
Citations Over TimeTop 16% of 2012 papers
Veera V. E. Ramesh, G. Priya, Amol S. Kotmale, Rajesh G. Gonnade, Pattuparambil R. Rajamohanan, Gangadhar J. Sanjayan
Abstract
Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.
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