Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults
British Journal of Clinical Pharmacology2015Vol. 81(2), pp. 235–245
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Ronald de Vries, Johan W. Smit, Peter Hellemans, James Jiao, Joseph Murphy, Donna Skee, Jan Snoeys, Juthamas Sukbuntherng, Maarten Vliegen, Loeckie De Zwart, Erik Mannaert, Jan de Jong
Abstract
The absolute oral bioavailability of ibrutinib was low, ranging from 3.9% in the fasting state to 8.4% when administered 30 min before a standard breakfast without GFJ and 15.9% with GFJ. Ibrutinib was well tolerated following a single oral and i.v. dose, under both fasted and fed conditions and regardless of GFJ intake status.
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