Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates
British Journal of Pharmacology2017Vol. 174(22), pp. 4173–4185
Citations Over TimeTop 16% of 2017 papers
Daniela Bumbaca Yadav, Janice Maloney, Kristin R. Wildsmith, Reina N. Fuji, William J. Meilandt, Hilda Solanoy, Yanmei Lu, Kun Peng, Blair Wilson, Pamela Chan, Kapil Gadkar, Andrew A. Kosky, Marisa S. Goo, Ann L. Daugherty, Jessica A. Couch, Thomas Keene, Karen Hayes, Lisa M. Jungbauer, Deanna Lane, Robert Switzer, Eric Adams, Ryan J. Watts, Kimberly Scearce‐Levie, Saileta Prabhu, Lisa Shafer, Deepak R. Thakker, Keith R. Hildebrand, Jasvinder K. Atwal
Abstract
I.c.v. administration of anti-BACE1 resulted in enhanced BACE1 target engagement and inhibition, with a corresponding dramatic reduction in CNS Aβ concentrations, due to enhanced brain exposure to antibody.
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