Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity
Journal of Medicinal Chemistry2005Vol. 48(18), pp. 5639–5643
Citations Over TimeTop 10% of 2005 papers
Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar, Balu Balasubramanian, Praveen Balimane, Patrick Brassil, Françis Beaulieu, ChiehYing Y. Chang, Wendy Clarke, Janet Dell, Jeffrey T. Eummer, David B. Frennesson, Marco M. Gottardis, Ann Greer, Steven Hansel, Warren Hurlburt, Bruce L. Jacobson, Subramaniam Krishnananthan, Francis Y. Lee, Aixin Li, Tai-An Lin, Peiying Liu, Carl Ouellet, Xiaopeng Sang, Mark G. Saulnier, Karen M. Stoffan, Yax Sun, Upender Velaparthi, Henry Ν. C. Wong, Zheng Yang, Kurt Zimmermann, Mary Zoeckler, Dolatrai M. Vyas
Abstract
Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivo biological activity of this interesting compound is also reported.
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