Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa 1Gary B. Phillips, Brad O. Buckman, David D. Davey, Keith A. Eagen, William J. Guilford, Josephine Hinchman, Elena Ho, Sunil Koovakkat, Amy Liang, David R. Light, Raju Mohan, Howard P. Ng, Joseph M. Post, Kenneth J. Shaw, Dave Smith, Babu Subramanyam, Mark E. Sullivan, Lan Trinh, Ron Vergona, Janette Walters, Kathy White, Marc Whitlow, Shung Wu, Wei Xu, and Michael M. MorrisseyView Author Information Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099 Cite this: J. Med. Chem. 1998, 41, 19, 3557–3562Publication Date (Web):August 15, 1998Publication History Received4 May 1998Published online15 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/jm980280hhttps://doi.org/10.1021/jm980280hrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views658Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Conformation,Inhibition,Inhibitors,Peptides and proteins,Phenyls Get e-Alerts

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