Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Journal of Medicinal Chemistry2009Vol. 52(24), pp. 7946–7949
Citations Over TimeTop 14% of 2009 papers
Patrick R. Verhoest, Caroline Proulx-LaFrance, Michael L. Corman, Lois K. Chenard, Christopher J. Helal, Xinjun Hou, Robin J. Kleiman, Shenping Liu, Eric S. Marr, Frank S. Menniti, Christopher Schmidt, Michelle Vanase‐Frawley, Anne W. Schmidt, Robert D. Williams, Frederick Nelson, Kari R. Fonseca, Spiros Liras
Abstract
By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.
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