Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics
MedChemComm2012Vol. 4(1), pp. 125–129
Citations Over Time
Jaclyn L. Henderson, Aarti Sawant‐Basak, Jamison B. Tuttle, Amy B. Dounay, Laura A. McAllister, Jayvardhan Pandit, Suo‐Bao Rong, Xinjun Hou, Bruce M. Bechle, Jiyoung Kim, Vinod D. Parikh, Somraj Ghosh, Edelweiss Evrard, Laura E. Zawadzke, Michelle A. Salafia, Brian Rago, R. Scott Obach, Alan Clark, Kari R. Fonseca, Cheng Chang, Patrick R. Verhoest
Abstract
A series of kynurenine aminotransferase II (KAT II) inhibitors has been developed replacing the hydroxamate motif with a bioisostere.
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